Transcriptome Sequencing Reveals Potential Mechanism of Cryptic 3’ Splice Site Selection in SF3B1-mutated Cancers

Mutations in the splicing factor SF3B1 are found in several cancer types and have been associated with various splicing defects. Using transcriptome sequencing data from chronic lymphocytic leukemia, breast cancer and uveal melanoma tumor samples, we show that hundreds of cryptic 3’ splice sites (3’...

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Bibliografiske detaljer
Udgivet i:PLoS Comput Biol
Main Authors: DeBoever, Christopher, Ghia, Emanuela M., Shepard, Peter J., Rassenti, Laura, Barrett, Christian L., Jepsen, Kristen, Jamieson, Catriona H. M., Carson, Dennis, Kipps, Thomas J., Frazer, Kelly A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358997/
https://ncbi.nlm.nih.gov/pubmed/25768983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004105
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