Transcriptome Sequencing Reveals Potential Mechanism of Cryptic 3’ Splice Site Selection in SF3B1-mutated Cancers

Mutations in the splicing factor SF3B1 are found in several cancer types and have been associated with various splicing defects. Using transcriptome sequencing data from chronic lymphocytic leukemia, breast cancer and uveal melanoma tumor samples, we show that hundreds of cryptic 3’ splice sites (3’...

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Argitaratua izan da:PLoS Comput Biol
Egile Nagusiak: DeBoever, Christopher, Ghia, Emanuela M., Shepard, Peter J., Rassenti, Laura, Barrett, Christian L., Jepsen, Kristen, Jamieson, Catriona H. M., Carson, Dennis, Kipps, Thomas J., Frazer, Kelly A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2015
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358997/
https://ncbi.nlm.nih.gov/pubmed/25768983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004105
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