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Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression

Vitiligo is an autoimmune disease in which melanocyte destruction causes skin depigmentation, with 49 loci known from previous GWAS. Aiming to define vitiligo subtypes, we discovered that age-of-onset is bimodal; one-third of cases have early onset (mean 10.3 years) and two-thirds later onset (mean...

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Bibliografske podrobnosti
izdano v:	Nat Commun
Main Authors:	Jin, Ying, Roberts, Genevieve H. L., Ferrara, Tracey M., Ben, Songtao, van Geel, Nanja, Wolkerstorfer, Albert, Ezzedine, Khaled, Siebert, Janet, Neff, Charles P., Palmer, Brent E., Santorico, Stephanie A., Spritz, Richard A.
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Publishing Group UK 2019
Teme:	Article
Online dostop:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6344500/ https://ncbi.nlm.nih.gov/pubmed/30674883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08337-4
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Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression

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