MHC class II super-enhancer increases surface expression of HLA-DR and HLA-DQ and affects cytokine production in autoimmune vitiligo

Genetic risk for autoimmunity in HLA genes is most often attributed to structural specificity resulting in presentation of self-antigens. Autoimmune vitiligo is strongly associated with the MHC class II region. Here, we fine-map vitiligo MHC class II genetic risk to three SNPs only 47 bp apart, loca...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Cavalli, Giulio, Hayashi, Masahiro, Jin, Ying, Yorgov, Daniel, Santorico, Stephanie A., Holcomb, Cherie, Rastrou, Melinda, Erlich, Henry, Tengesdal, Isak W., Dagna, Lorenzo, Neff, C. Preston, Palmer, Brent E., Spritz, Richard A., Dinarello, Charles A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2016
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747741/
https://ncbi.nlm.nih.gov/pubmed/26787888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523482113
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