Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression

Vitiligo is an autoimmune disease in which melanocyte destruction causes skin depigmentation, with 49 loci known from previous GWAS. Aiming to define vitiligo subtypes, we discovered that age-of-onset is bimodal; one-third of cases have early onset (mean 10.3 years) and two-thirds later onset (mean...

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Vydáno v:Nat Commun
Hlavní autoři: Jin, Ying, Roberts, Genevieve H. L., Ferrara, Tracey M., Ben, Songtao, van Geel, Nanja, Wolkerstorfer, Albert, Ezzedine, Khaled, Siebert, Janet, Neff, Charles P., Palmer, Brent E., Santorico, Stephanie A., Spritz, Richard A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344500/
https://ncbi.nlm.nih.gov/pubmed/30674883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08337-4
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