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Deep genotype imputation captures virtually all heritability of autoimmune vitiligo

Autoimmune vitiligo is a complex disease involving polygenic risk from at least 50 loci previously identified by genome-wide association studies. The objectives of this study were to estimate and compare vitiligo heritability in European-derived patients using both family-based and ‘deep imputation’...

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Vydáno v:Hum Mol Genet
Hlavní autoři: Roberts, Genevieve H L, Santorico, Stephanie A, Spritz, Richard A
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7104671/
https://ncbi.nlm.nih.gov/pubmed/31943001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddaa005
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