Concomitant Enhancement of HIV-1 Replication Potential and Neutralization-Resistance in Concert With Three Adaptive Mutations in Env V1/C2/C4 Domains

HIV-1 Env protein functions in the entry process and is the target of neutralizing antibodies. Its intrinsically high mutation rate is certainly one of driving forces for persistence/survival in hosts. For optimal replication in various environments, HIV-1 Env must continue to adapt and evolve throu...

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Publicat a:Front Microbiol
Autors principals: Doi, Naoya, Yokoyama, Masaru, Koma, Takaaki, Kotani, Osamu, Sato, Hironori, Adachi, Akio, Nomaguchi, Masako
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019
Matèries:
Microbiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344430/
https://ncbi.nlm.nih.gov/pubmed/30705669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2019.00002
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