Allosteric Regulation of HIV-1 Capsid Structure for Gag Assembly, Virion Production, and Viral Infectivity by a Disordered Interdomain Linker

The retroviral Gag capsid (Gag-CA) interdomain linker is an unstructured peptide segment connecting structured N-terminal and C-terminal domains. Although the region is reported to play roles in virion morphogenesis and infectivity, underlying molecular mechanisms remain unexplored. To address this...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Koma, Takaaki, Kotani, Osamu, Miyakawa, Kei, Ryo, Akihide, Yokoyama, Masaru, Doi, Naoya, Adachi, Akio, Sato, Hironori, Nomaguchi, Masako
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2019
Schlagworte:
Structure and Assembly
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6694816/
https://ncbi.nlm.nih.gov/pubmed/31189701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00381-19
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