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Species-Specific Valid Ternary Interactions of HIV-1 Env-gp120, CD4, and CCR5 as Revealed by an Adaptive Single-Amino Acid Substitution at the V3 Loop Tip

Molecular interactions of the variable envelope gp120 subunit of HIV-1 with two cellular receptors are the first step of viral infection, thereby playing pivotal roles in determining viral infectivity and cell tropism. However, the underlying regulatory mechanisms for interactions under gp120 sponta...

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發表在:J Virol
Main Authors: Koma, Takaaki, Yokoyama, Masaru, Kotani, Osamu, Doi, Naoya, Nakanishi, Nina, Okubo, Hayato, Adachi, Shun, Adachi, Akio, Sato, Hironori, Nomaguchi, Masako
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2021
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8315996/
https://ncbi.nlm.nih.gov/pubmed/33883222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02177-20
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