Impaired LXRα Phosphorylation Attenuates Progression of Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) is a very common indication for liver transplantation. How fat-rich diets promote progression from fatty liver to more damaging inflammatory and fibrotic stages is poorly understood. Here, we show that disrupting phosphorylation at Ser196 (S196A) in the live...

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Pubblicato in:Cell Rep
Autori principali: Becares, Natalia, Gage, Matthew C., Voisin, Maud, Shrestha, Elina, Martin-Gutierrez, Lucia, Liang, Ning, Louie, Rikah, Pourcet, Benoit, Pello, Oscar M., Luong, Tu Vinh, Goñi, Saioa, Pichardo-Almarza, Cesar, Røberg-Larsen, Hanne, Diaz-Zuccarini, Vanessa, Steffensen, Knut R., O’Brien, Alastair, Garabedian, Michael J., Rombouts, Krista, Treuter, Eckardt, Pineda-Torra, Inés
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344342/
https://ncbi.nlm.nih.gov/pubmed/30673619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.12.094
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