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Virally Mediated Overexpression of Glial-Derived Neurotrophic Factor Elicits Age- and Dose-Dependent Neuronal Toxicity and Hearing Loss

Contemporary cochlear implants (CI) are generally very effective for remediation of severe to profound sensorineural hearing loss, but outcomes are still highly variable. Auditory nerve survival is likely one of the major factors underlying this variability. Neurotrophin therapy therefore has been p...

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Detalhes bibliográficos
Publicado no:Hum Gene Ther
Main Authors: Akil, Omar, Blits, Bas, Lustig, Lawrence R., Leake, Patricia A.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6343370/
https://ncbi.nlm.nih.gov/pubmed/30183384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2018.028
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