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Virally Mediated Overexpression of Glial-Derived Neurotrophic Factor Elicits Age- and Dose-Dependent Neuronal Toxicity and Hearing Loss

Contemporary cochlear implants (CI) are generally very effective for remediation of severe to profound sensorineural hearing loss, but outcomes are still highly variable. Auditory nerve survival is likely one of the major factors underlying this variability. Neurotrophin therapy therefore has been p...

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Détails bibliographiques
Publié dans:Hum Gene Ther
Auteurs principaux: Akil, Omar, Blits, Bas, Lustig, Lawrence R., Leake, Patricia A.
Format: Artigo
Langue:Inglês
Publié: Mary Ann Liebert, Inc., publishers 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6343370/
https://ncbi.nlm.nih.gov/pubmed/30183384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2018.028
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