Conformational Dynamics in the Core of Human Y145Stop Prion Protein Amyloid Probed by Relaxation Dispersion NMR

Microsecond to millisecond timescale backbone dynamics of the amyloid core residues in Y145Stop human prion protein (PrP) fibrils were investigated by using (15)N rotating frame (R(1ρ)) relaxation dispersion solid-state nuclear magnetic resonance spectroscopy over a wide range of spin-lock fields. N...

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Publicado no:Chemphyschem
Main Authors: Shannon, Matthew D., Theint, Theint, Mukhopadhyay, Dwaipayan, Surewicz, Krystyna, Surewicz, Witold K., Marion, Dominique, Schanda, Paul, Jaroniec, Christopher P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6342661/
https://ncbi.nlm.nih.gov/pubmed/30276945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cphc.201800779
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