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Targeting fatty-acid amide hydrolase with prodrugs for CNS-selective therapy
The blood-brain barrier (BBB) can be a substantial impediment to achieving therapeutic levels of drugs in the CNS. Certain chemical functionality such as the carboxylic acid is a general liability for BBB permeability preventing significant CNS distribution of a drug from a systemic dose. Here, we r...
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| Publicado no: | ACS Chem Neurosci |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6342467/ https://ncbi.nlm.nih.gov/pubmed/28756656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.7b00239 |
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