Structure–Activity Relationships of Central Nervous System Penetration by Fatty Acid Amide Hydrolase (FAAH)-Targeted Thyromimetic Prodrugs

[Image: see text] Thyroid hormone (TH) action is of clinical interest in treating demyelinating diseases of the central nervous system (CNS). Two amide prodrugs of sobetirome, a potent thyroid hormone agonist, were previously shown to significantly improve CNS selective distribution of the parent dr...

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Publicat a:ACS Med Chem Lett
Autors principals: Meinig, J. Matthew, Ferrara, Skylar J., Banerji, Tapasree, Banerji, Tania, Sanford-Crane, Hannah S., Bourdette, Dennis, Scanlan, Thomas S.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2018
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6331174/
https://ncbi.nlm.nih.gov/pubmed/30655956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00501
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