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Increasing Thyromimetic Potency Through Halogen Substitution
Sobetirome is one of the most studied TRβ-selective thyromimetics in the field due to its excellent selectivity and potency. A small structural change - replacing the 3,5-dimethyl groups of sobetirome with either chlorine or bromine - produces significantly more potent compounds, both in vitro and i...
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| Publicado en: | ChemMedChem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5389920/ https://ncbi.nlm.nih.gov/pubmed/27731931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201600408 |
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