Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes

OBJECTIVE: Abnormally elevated proinsulin secretion has been reported in type 2 and early type 1 diabetes when significant C-peptide is present. We questioned whether individuals with long-standing type 1 diabetes and low or absent C-peptide secretory capacity retained the ability to make proinsulin...

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發表在:Diabetes Care
Main Authors: Sims, Emily K., Bahnson, Henry T., Nyalwidhe, Julius, Haataja, Leena, Davis, Asa K., Speake, Cate, DiMeglio, Linda A., Blum, Janice, Morris, Margaret A., Mirmira, Raghavendra G., Nadler, Jerry, Mastracci, Teresa L., Marcovina, Santica, Qian, Wei-Jun, Yi, Lian, Swensen, Adam C., Yip-Schneider, Michele, Schmidt, C. Max, Considine, Robert V., Arvan, Peter, Greenbaum, Carla J., Evans-Molina, Carmella
格式: Artigo
語言:Inglês
出版: American Diabetes Association 2019
主題:
Pathophysiology/Complications
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6341288/
https://ncbi.nlm.nih.gov/pubmed/30530850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/dc17-2625
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