Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes

OBJECTIVE: Abnormally elevated proinsulin secretion has been reported in type 2 and early type 1 diabetes when significant C-peptide is present. We questioned whether individuals with long-standing type 1 diabetes and low or absent C-peptide secretory capacity retained the ability to make proinsulin...

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Détails bibliographiques
Publié dans:Diabetes Care
Auteurs principaux: Sims, Emily K., Bahnson, Henry T., Nyalwidhe, Julius, Haataja, Leena, Davis, Asa K., Speake, Cate, DiMeglio, Linda A., Blum, Janice, Morris, Margaret A., Mirmira, Raghavendra G., Nadler, Jerry, Mastracci, Teresa L., Marcovina, Santica, Qian, Wei-Jun, Yi, Lian, Swensen, Adam C., Yip-Schneider, Michele, Schmidt, C. Max, Considine, Robert V., Arvan, Peter, Greenbaum, Carla J., Evans-Molina, Carmella
Format: Artigo
Langue:Inglês
Publié: American Diabetes Association 2019
Sujets:
Pathophysiology/Complications
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6341288/
https://ncbi.nlm.nih.gov/pubmed/30530850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/dc17-2625
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