Elevations in the Fasting Serum Proinsulin–to–C-Peptide Ratio Precede the Onset of Type 1 Diabetes

OBJECTIVE: We tested whether an elevation in the serum proinsulin–to–C-peptide ratio (PI:C), a biomarker of β-cell endoplasmic reticulum (ER) dysfunction, was associated with progression to type 1 diabetes. RESEARCH DESIGN AND METHODS: Fasting total PI and C levels were measured in banked serum samp...

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Bibliographic Details
Published in:Diabetes Care
Main Authors: Sims, Emily K., Chaudhry, Zunaira, Watkins, Renecia, Syed, Farooq, Blum, Janice, Ouyang, Fangqian, Perkins, Susan M., Mirmira, Raghavendra G., Sosenko, Jay, DiMeglio, Linda A., Evans-Molina, Carmella
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2016
Subjects:
Clinical Care/Education/Nutrition/Psychosocial Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001142/
https://ncbi.nlm.nih.gov/pubmed/27385327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/dc15-2849
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