Elevations in Circulating Methylated and Unmethylated Preproinsulin DNA in New-Onset Type 1 Diabetes

Elevated ratios of circulating unmethylated to methylated preproinsulin (INS) DNA have been suggested to reflect β-cell death in type 1 diabetes (T1D). We tested the hypothesis that absolute levels (rather than ratios) of unmethylated and methylated INS DNA differ between subjects with new-onset T1D...

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Bibliografske podrobnosti
izdano v:Diabetes
Main Authors: Fisher, Marisa M., Watkins, Renecia A., Blum, Janice, Evans-Molina, Carmella, Chalasani, Naga, DiMeglio, Linda A., Mather, Kieren J., Tersey, Sarah A., Mirmira, Raghavendra G.
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2015
Teme:
Islet Studies
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613977/
https://ncbi.nlm.nih.gov/pubmed/26216854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-0430
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