Exploiting regulatory heterogeneity to systematically identify enhancers with high accuracy

Identifying functional enhancer elements in metazoan systems is a major challenge. Large-scale validation of enhancers predicted by ENCODE reveal false-positive rates of at least 70%. We used the pregrastrula-patterning network of Drosophila melanogaster to demonstrate that loss in accuracy in held-...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Arbel, Hamutal, Basu, Sumanta, Fisher, William W., Hammonds, Ann S., Wan, Kenneth H., Park, Soo, Weiszmann, Richard, Booth, Benjamin W., Keranen, Soile V., Henriquez, Clara, Shams Solari, Omid, Bickel, Peter J., Biggin, Mark D., Celniker, Susan E., Brown, James B.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338827/
https://ncbi.nlm.nih.gov/pubmed/30598455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1808833115
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