Exploiting regulatory heterogeneity to systematically identify enhancers with high accuracy

Identifying functional enhancer elements in metazoan systems is a major challenge. Large-scale validation of enhancers predicted by ENCODE reveal false-positive rates of at least 70%. We used the pregrastrula-patterning network of Drosophila melanogaster to demonstrate that loss in accuracy in held-...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Arbel, Hamutal, Basu, Sumanta, Fisher, William W., Hammonds, Ann S., Wan, Kenneth H., Park, Soo, Weiszmann, Richard, Booth, Benjamin W., Keranen, Soile V., Henriquez, Clara, Shams Solari, Omid, Bickel, Peter J., Biggin, Mark D., Celniker, Susan E., Brown, James B.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338827/
https://ncbi.nlm.nih.gov/pubmed/30598455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1808833115
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