Exploiting regulatory heterogeneity to systematically identify enhancers with high accuracy

Identifying functional enhancer elements in metazoan systems is a major challenge. Large-scale validation of enhancers predicted by ENCODE reveal false-positive rates of at least 70%. We used the pregrastrula-patterning network of Drosophila melanogaster to demonstrate that loss in accuracy in held-...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Arbel, Hamutal, Basu, Sumanta, Fisher, William W., Hammonds, Ann S., Wan, Kenneth H., Park, Soo, Weiszmann, Richard, Booth, Benjamin W., Keranen, Soile V., Henriquez, Clara, Shams Solari, Omid, Bickel, Peter J., Biggin, Mark D., Celniker, Susan E., Brown, James B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338827/
https://ncbi.nlm.nih.gov/pubmed/30598455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1808833115
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