Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity

Metformin, the first-line drug to treat type 2 diabetes (T2D), inhibits mitochondrial glycerolphosphate dehydrogenase in the liver to suppress gluconeogenesis. However, the direct target and the underlying mechanisms by which metformin increases glucose uptake in peripheral tissues remain uncharacte...

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Vydáno v:FASEB J
Hlavní autoři: Polianskyte-Prause, Zydrune, Tolvanen, Tuomas A., Lindfors, Sonja, Dumont, Vincent, Van, Mervi, Wang, Hong, Dash, Surjya N., Berg, Mika, Naams, Jette-Britt, Hautala, Laura C., Nisen, Harry, Mirtti, Tuomas, Groop, Per-Henrik, Wähälä, Kristiina, Tienari, Jukka, Lehtonen, Sanna
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338644/
https://ncbi.nlm.nih.gov/pubmed/30321069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201800529RR
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