Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity

Metformin, the first-line drug to treat type 2 diabetes (T2D), inhibits mitochondrial glycerolphosphate dehydrogenase in the liver to suppress gluconeogenesis. However, the direct target and the underlying mechanisms by which metformin increases glucose uptake in peripheral tissues remain uncharacte...

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Опубликовано в: :FASEB J
Главные авторы: Polianskyte-Prause, Zydrune, Tolvanen, Tuomas A., Lindfors, Sonja, Dumont, Vincent, Van, Mervi, Wang, Hong, Dash, Surjya N., Berg, Mika, Naams, Jette-Britt, Hautala, Laura C., Nisen, Harry, Mirtti, Tuomas, Groop, Per-Henrik, Wähälä, Kristiina, Tienari, Jukka, Lehtonen, Sanna
Формат: Artigo
Язык:Inglês
Опубликовано: Federation of American Societies for Experimental Biology 2019
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338644/
https://ncbi.nlm.nih.gov/pubmed/30321069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201800529RR
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