Early-Onset Diabetic E1-DN Mice Develop Albuminuria and Glomerular Injury Typical of Diabetic Nephropathy

The transgenic E1-DN mice express a kinase-negative epidermal growth factor receptor in their pancreatic islets and are diabetic from two weeks of age due to impaired postnatal growth of β-cell mass. Here, we characterize the development of hyperglycaemia-induced renal injury in the E1-DN mice. Homo...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Hyvönen, Mervi E., Dumont, Vincent, Tienari, Jukka, Lehtonen, Eero, Ustinov, Jarkko, Havana, Marika, Jalanko, Hannu, Otonkoski, Timo, Miettinen, Päivi J., Lehtonen, Sanna
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426768/
https://ncbi.nlm.nih.gov/pubmed/26000279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/102969
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