PACSIN2 accelerates nephrin trafficking and is up-regulated in diabetic kidney disease

Nephrin is a core component of podocyte (glomerular epithelial cell) slit diaphragm and is required for kidney ultrafiltration. Down-regulation or mislocalization of nephrin has been observed in diabetic kidney disease (DKD), characterized by albuminuria. Here, we investigate the role of protein kin...

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Bibliografiske detaljer
Udgivet i:FASEB J
Main Authors: Dumont, Vincent, Tolvanen, Tuomas A., Kuusela, Sara, Wang, Hong, Nyman, Tuula A., Lindfors, Sonja, Tienari, Jukka, Nisen, Harry, Suetsugu, Shiro, Plomann, Markus, Kawachi, Hiroshi, Lehtonen, Sanna
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572687/
https://ncbi.nlm.nih.gov/pubmed/28550045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201601265R
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