Adiponectin receptor agonist AdipoRon ameliorates renal inflammation in diet-induced obese mice and endotoxin-treated human glomeruli ex vivo

AIMS/HYPOTHESIS: Chronic low-grade inflammation with local upregulation of proinflammatory molecules plays a role in the progression of obesity-related renal injury. Reduced serum concentration of anti-inflammatory adiponectin may promote chronic inflammation. Here, we investigated the potential ant...

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Gepubliceerd in:Diabetologia
Hoofdauteurs: Lindfors, Sonja, Polianskyte-Prause, Zydrune, Bouslama, Rim, Lehtonen, Eero, Mannerla, Miia, Nisen, Harry, Tienari, Jukka, Salmenkari, Hanne, Forsgård, Richard, Mirtti, Tuomas, Lehto, Markku, Groop, Per-Henrik, Lehtonen, Sanna
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer Berlin Heidelberg 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8245393/
https://ncbi.nlm.nih.gov/pubmed/33987714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-021-05473-9
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