IRE1α Activation in Bone Marrow-Derived Dendritic Cells Modulates Innate Recognition of Melanoma Cells and Favors CD8(+) T Cell Priming

The IRE1α/XBP1s signaling pathway is an arm of the unfolded protein response (UPR) that safeguards the fidelity of the cellular proteome during endoplasmic reticulum (ER) stress, and that has also emerged as a key regulator of dendritic cell (DC) homeostasis. However, in the context of DC activation...

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Dades bibliogràfiques
Publicat a:Front Immunol
Autors principals: Medel, Bernardita, Costoya, Cristobal, Fernandez, Dominique, Pereda, Cristian, Lladser, Alvaro, Sauma, Daniela, Pacheco, Rodrigo, Iwawaki, Takao, Salazar-Onfray, Flavio, Osorio, Fabiola
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338037/
https://ncbi.nlm.nih.gov/pubmed/30687308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.03050
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