IRE1α Activation in Bone Marrow-Derived Dendritic Cells Modulates Innate Recognition of Melanoma Cells and Favors CD8(+) T Cell Priming

The IRE1α/XBP1s signaling pathway is an arm of the unfolded protein response (UPR) that safeguards the fidelity of the cellular proteome during endoplasmic reticulum (ER) stress, and that has also emerged as a key regulator of dendritic cell (DC) homeostasis. However, in the context of DC activation...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Medel, Bernardita, Costoya, Cristobal, Fernandez, Dominique, Pereda, Cristian, Lladser, Alvaro, Sauma, Daniela, Pacheco, Rodrigo, Iwawaki, Takao, Salazar-Onfray, Flavio, Osorio, Fabiola
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338037/
https://ncbi.nlm.nih.gov/pubmed/30687308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.03050
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