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Different SUMO paralogues determine the fate of wild-type and mutant CFTRs: biogenesis versus degradation
A pathway for cystic fibrosis transmembrane conductance regulator (CFTR) degradation is initiated by Hsp27, which cooperates with Ubc9 and binds to the common F508del mutant to modify it with SUMO-2/3. These SUMO paralogues form polychains, which are recognized by the ubiquitin ligase, RNF4, for pro...
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| Publicado no: | Mol Biol Cell |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6337916/ https://ncbi.nlm.nih.gov/pubmed/30403549 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E18-04-0252 |
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