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The biogenesis of chromosome translocations

Chromosome translocations are catastrophic genomic events and often play key roles in tumorigenesis. Yet the biogenesis of chromosome translocations is remarkably poorly understood. Recent work has delineated several distinct mechanistic steps in the formation of translocations, and it has become ap...

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Udgivet i:Nat Cell Biol
Main Authors: Roukos, Vassilis, Misteli, Tom
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6337718/
https://ncbi.nlm.nih.gov/pubmed/24691255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2941
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