MHY440, a Novel Topoisomerase Ι Inhibitor, Induces Cell Cycle Arrest and Apoptosis via a ROS-Dependent DNA Damage Signaling Pathway in AGS Human Gastric Cancer Cells

We investigated the antitumor activity and action mechanism of MHY440 in AGS human gastric cancer cells. MHY440 inhibited topoisomerase (Topo) Ι activity and was associated with a DNA damage response signaling pathway. It exhibited a stronger anti-proliferative effect on AGS cells relative to Hs27 h...

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Vydáno v:Molecules
Hlavní autoři: Jang, Jung Yoon, Kang, Yong Jung, Sung, Bokyung, Kim, Min Jeong, Park, Chaeun, Kang, Dongwan, Moon, Hyung Ryong, Chung, Hae Young, Kim, Nam Deuk
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6337620/
https://ncbi.nlm.nih.gov/pubmed/30597845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24010096
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