A New Synthetic Histone Deacetylase Inhibitor, MHY2256, Induces Apoptosis and Autophagy Cell Death in Endometrial Cancer Cells via p53 Acetylation

We previously discovered a novel sirtuin (SIRT) inhibitor, MHY2256, that exerts anticancer activity through p53 acetylation in MCF-7 human breast cancer cells. We investigated the anticancer activity of MHY2256 against hormone-related cancer, an endometrial cancer with a poor prognosis. The IC(50) v...

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Publicado en:Int J Mol Sci
Autores principales: De, Umasankar, Son, Ji Yeon, Sachan, Richa, Park, Yu Jin, Kang, Dongwan, Yoon, Kyungsil, Lee, Byung Mu, Kim, In Su, Moon, Hyung Ryong, Kim, Hyung Sik
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6164480/
https://ncbi.nlm.nih.gov/pubmed/30217020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19092743
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