Novel SIRT Inhibitor, MHY2256, Induces Cell Cycle Arrest, Apoptosis, and Autophagic Cell Death in HCT116 Human Colorectal Cancer Cells

We examined the anticancer effects of a novel sirtuin inhibitor, MHY2256, on HCT116 human colorectal cancer cells to investigate its underlying molecular mechanisms. MHY2256 significantly suppressed the activity of sirtuin 1 and expression levels of sirtuin 1/2 and stimulated acetylation of forkhead...

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Bibliografiset tiedot
Julkaisussa:Biomol Ther (Seoul)
Päätekijät: Kim, Min Jeong, Kang, Young Jung, Sung, Bokyung, Jang, Jung Yoon, Ahn, Yu Ra, Oh, Hye Jin, Choi, Heejeong, Choi, Inkyu, Im, Eunok, Moon, Hyung Ryong, Chung, Hae Young, Kim, Nam Deuk
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Korean Society of Applied Pharmacology 2020
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Original Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7585637/
https://ncbi.nlm.nih.gov/pubmed/33073770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4062/biomolther.2020.153
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