Novel SIRT Inhibitor, MHY2256, Induces Cell Cycle Arrest, Apoptosis, and Autophagic Cell Death in HCT116 Human Colorectal Cancer Cells

We examined the anticancer effects of a novel sirtuin inhibitor, MHY2256, on HCT116 human colorectal cancer cells to investigate its underlying molecular mechanisms. MHY2256 significantly suppressed the activity of sirtuin 1 and expression levels of sirtuin 1/2 and stimulated acetylation of forkhead...

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Foilsithe in:Biomol Ther (Seoul)
Main Authors: Kim, Min Jeong, Kang, Young Jung, Sung, Bokyung, Jang, Jung Yoon, Ahn, Yu Ra, Oh, Hye Jin, Choi, Heejeong, Choi, Inkyu, Im, Eunok, Moon, Hyung Ryong, Chung, Hae Young, Kim, Nam Deuk
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Korean Society of Applied Pharmacology 2020
Ábhair:
Original Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7585637/
https://ncbi.nlm.nih.gov/pubmed/33073770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4062/biomolther.2020.153
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