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Roco Proteins: GTPases with a Baroque Structure and Mechanism

Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of genetically inherited Parkinson’s Disease (PD). LRRK2 is a large, multi-domain protein belonging to the Roco protein family, a family of GTPases characterized by a central RocCOR (Ras of complex proteins/C-terminal of Roc) domai...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Wauters, Lina, Versées, Wim, Kortholt, Arjan
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6337361/
https://ncbi.nlm.nih.gov/pubmed/30609797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20010147
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