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Multiple Regulatory Mechanisms for the Dictyostelium Roco Protein GbpC

GbpC is a multidomain Roco protein in Dictyostelium, involved in transduction of intracellular cGMP that is produced by chemotactic signals. We have shown previously that cGMP binding to GbpC induces an intramolecular signaling cascade by activating subsequently the GEF, Ras, and kinase domains. In...

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Detalhes bibliográficos
Main Authors: Kortholt, Arjan, van Egmond, Wouter N., Plak, Katarzyna, Bosgraaf, Leonard, Keizer-Gunnink, Ineke, van Haastert, Peter J. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268432/
https://ncbi.nlm.nih.gov/pubmed/22119747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.315739
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