Multiple Regulatory Mechanisms for the Dictyostelium Roco Protein GbpC

GbpC is a multidomain Roco protein in Dictyostelium, involved in transduction of intracellular cGMP that is produced by chemotactic signals. We have shown previously that cGMP binding to GbpC induces an intramolecular signaling cascade by activating subsequently the GEF, Ras, and kinase domains. In...

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Bibliographic Details
Main Authors: Kortholt, Arjan, van Egmond, Wouter N., Plak, Katarzyna, Bosgraaf, Leonard, Keizer-Gunnink, Ineke, van Haastert, Peter J. M.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268432/
https://ncbi.nlm.nih.gov/pubmed/22119747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.315739
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