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In silico Assessment of Pharmacotherapy for Human Atrial Patho-Electrophysiology Associated With hERG-Linked Short QT Syndrome
Short QT syndrome variant 1 (SQT1) arises due to gain-of-function mutations to the human Ether-à-go-go-Related Gene (hERG), which encodes the α subunit of channels carrying rapid delayed rectifier potassium current, I(Kr). In addition to QT interval shortening and ventricular arrhythmias, SQT1 is as...
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| Vydáno v: | Front Physiol |
|---|---|
| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Frontiers Media S.A.
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6336736/ https://ncbi.nlm.nih.gov/pubmed/30687112 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.01888 |
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