Human Atrial Arrhythmogenesis and Sinus Bradycardia in KCNQ1-Linked Short QT Syndrome: Insights From Computational Modelling

Atrial fibrillation (AF) and sinus bradycardia have been reported in patients with short QT syndrome variant 2 (SQT2), which is underlain by gain-of-function mutations in KCNQ1 encoding the α subunit of channels carrying slow delayed rectifier potassium current, I(Ks). However, the mechanism(s) unde...

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Publicado en:Front Physiol
Autores principales: Whittaker, Dominic G., Colman, Michael A., Ni, Haibo, Hancox, Jules C., Zhang, Henggui
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2018
Materias:
Physiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6180159/
https://ncbi.nlm.nih.gov/pubmed/30337886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.01402
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