Human Atrial Arrhythmogenesis and Sinus Bradycardia in KCNQ1-Linked Short QT Syndrome: Insights From Computational Modelling

Atrial fibrillation (AF) and sinus bradycardia have been reported in patients with short QT syndrome variant 2 (SQT2), which is underlain by gain-of-function mutations in KCNQ1 encoding the α subunit of channels carrying slow delayed rectifier potassium current, I(Ks). However, the mechanism(s) unde...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Front Physiol
Hlavní autoři: Whittaker, Dominic G., Colman, Michael A., Ni, Haibo, Hancox, Jules C., Zhang, Henggui
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Physiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6180159/
https://ncbi.nlm.nih.gov/pubmed/30337886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.01402
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky