Nociceptor Translational Profiling Reveals the Ragulator-Rag GTPase Complex as a Critical Generator of Neuropathic Pain

Nociceptors, sensory neurons in the DRG that detect damaging or potentially damaging stimuli, are key drivers of neuropathic pain. Injury to these neurons causes activation of translation regulation signaling, including the mechanistic target of rapamycin complex 1 (mTORC1) and mitogen-activated pro...

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Vydáno v:J Neurosci
Hlavní autoři: Megat, Salim, Ray, Pradipta R., Moy, Jamie K., Lou, Tzu-Fang, Barragán-Iglesias, Paulino, Li, Yan, Pradhan, Grishma, Wanghzou, Andi, Ahmad, Ayesha, Burton, Michael D., North, Robert Y., Dougherty, Patrick M., Khoutorsky, Arkady, Sonenberg, Nahum, Webster, Kevin R., Dussor, Gregory, Campbell, Zachary T., Price, Theodore J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6335757/
https://ncbi.nlm.nih.gov/pubmed/30459229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2661-18.2018
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