Recurrent activating mutations of PPARγ associated with luminal bladder tumors

The upregulation of PPARγ/RXRα transcriptional activity has emerged as a key event in luminal bladder tumors. It renders tumor cell growth PPARγ-dependent and modulates the tumor microenvironment to favor escape from immuno-surveillance. The activation of the pathway has been linked to PPARG gains/a...

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Publicat a:Nat Commun
Autors principals: Rochel, Natacha, Krucker, Clémentine, Coutos-Thévenot, Laure, Osz, Judit, Zhang, Ruiyun, Guyon, Elodie, Zita, Wayne, Vanthong, Séverin, Hernandez, Oscar Alba, Bourguet, Maxime, Badawy, Kays Al, Dufour, Florent, Peluso-Iltis, Carole, Heckler-Beji, Syrine, Dejaegere, Annick, Kamoun, Aurélie, de Reyniès, Aurélien, Neuzillet, Yann, Rebouissou, Sandra, Béraud, Claire, Lang, Hervé, Massfelder, Thierry, Allory, Yves, Cianférani, Sarah, Stote, Roland H., Radvanyi, François, Bernard-Pierrot, Isabelle
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6335423/
https://ncbi.nlm.nih.gov/pubmed/30651555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-08157-y
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