IGF1R activation and the in vitro antiproliferative efficacy of IGF1R inhibitor are inversely correlated with IGFBP5 expression in bladder cancer

BACKGROUND: The insulin growth factor (IGF) pathway has been proposed as a potential therapeutic target in bladder cancer. We characterized the expression of components of the IGF pathway — insulin growth factor receptors (INSR, IGF1R, IGF2R), ligands (INS, IGF1, IGF2), and binding proteins (IGFBP1–...

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Bibliografske podrobnosti
izdano v:BMC Cancer
Main Authors: Neuzillet, Yann, Chapeaublanc, Elodie, Krucker, Clémentine, De Koning, Leanne, Lebret, Thierry, Radvanyi, François, Bernard-Pierrot, Isabelle
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2017
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5588742/
https://ncbi.nlm.nih.gov/pubmed/28882129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3618-5
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