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Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors
Transcription regulation by steroid hormones, vitamin derivatives, and metabolites is mediated by nuclear receptors (NRs), which play an important role in ligand-dependent gene expression and human health. NRs function as homodimers or heterodimers and are involved in a combinatorial, coordinated an...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3309777/ https://ncbi.nlm.nih.gov/pubmed/22355136 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118192109 |
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