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Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors

Transcription regulation by steroid hormones, vitamin derivatives, and metabolites is mediated by nuclear receptors (NRs), which play an important role in ligand-dependent gene expression and human health. NRs function as homodimers or heterodimers and are involved in a combinatorial, coordinated an...

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Bibliografske podrobnosti
Main Authors: Osz, Judit, Brélivet, Yann, Peluso-Iltis, Carole, Cura, Vincent, Eiler, Sylvia, Ruff, Marc, Bourguet, William, Rochel, Natacha, Moras, Dino
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3309777/
https://ncbi.nlm.nih.gov/pubmed/22355136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118192109
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