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The D253N Mutation in the Polymerase Basic 2 Gene in Avian Influenza (H9N2) Virus Contributes to the Pathogenesis of the Virus in Mammalian Hosts

Mutations in the polymerase basic 2 (PB2) gene of avian influenza viruses are important signatures for their adaptation to mammalian hosts. Various adaptive mutations have been identified around the 627 and nuclear localization sequence (NLS) domains of PB2 protein, and these mutations contribute to...

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Bibliografiske detaljer
Udgivet i:Virol Sin
Main Authors: Zhang, Jinfeng, Su, Rong, Jian, Xiaoyun, An, Hongliang, Jiang, Ronbing, Mok, Chris Ka Pun
Format: Artigo
Sprog:Inglês
Udgivet: Springer Singapore 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6335224/
https://ncbi.nlm.nih.gov/pubmed/30569291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12250-018-0072-8
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