Amino Acid Substitutions in Polymerase Basic Protein 2 Gene Contribute to the Pathogenicity of the Novel A/H7N9 Influenza Virus in Mammalian Hosts

A novel avian-origin influenza A/H7N9 virus emerged in 2013 to cause more than 130 cases of zoonotic human disease, with an overall case fatality rate of around 30% in cases detected. It has been shown that an E-to-K amino acid change at residue 627 of polymerase basic protein 2 (PB2) occurred frequ...

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Bibliografiske detaljer
Main Authors: Mok, Chris Ka Pun, Lee, Horace Hok Yeung, Lestra, Maxime, Nicholls, John Malcolm, Chan, Michael Chi Wai, Sia, Sin Fun, Zhu, Huachen, Poon, Leo Lit Man, Guan, Yi, Peiris, Joseph Sriyal Malik
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3957932/
https://ncbi.nlm.nih.gov/pubmed/24403592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02740-13
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