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Amino Acid Residues 253 and 591 of the PB2 Protein of Avian Influenza Virus A H9N2 Contribute to Mammalian Pathogenesis

We investigated the tropism, host responses, and virulence of two variants of A/Quail/Hong Kong/G1/1997 (H9N2) (H9N2/G1) with D253N and Q591K in the PB2 protein in primary human macrophages and bronchial epithelium in vitro and in mice in vivo. Virus with PB2 D253N and Q591K had greater polymerase a...

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Bibliografiske detaljer
Main Authors: Mok, Chris Ka Pun, Yen, Hui Ling, Yu, May Yan Mei, Yuen, Kit Man, Sia, Sin Fun, Chan, Michael Chi Wai, Qin, Gang, Tu, Wen Wei, Peiris, Joseph Sriyal Malik
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165745/
https://ncbi.nlm.nih.gov/pubmed/21734052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00702-11
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