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The impact of early phase trial design in the drug development process
PURPOSE: Many of the therapeutic agents that are being used currently were developed using the 3+3 decision rule for dose-finding. Over the past 30 years, several dose-finding designs have been proposed and evaluated, including the ‘continual reassessment method’ (CRM) and the ‘Bayesian optimal inte...
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| Pubblicato in: | Clin Cancer Res |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6335181/ https://ncbi.nlm.nih.gov/pubmed/30327310 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0203 |
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