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The impact of early phase trial design in the drug development process

PURPOSE: Many of the therapeutic agents that are being used currently were developed using the 3+3 decision rule for dose-finding. Over the past 30 years, several dose-finding designs have been proposed and evaluated, including the ‘continual reassessment method’ (CRM) and the ‘Bayesian optimal inte...

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Dettagli Bibliografici
Pubblicato in:Clin Cancer Res
Autori principali: Conaway, Mark R., Petroni, Gina R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6335181/
https://ncbi.nlm.nih.gov/pubmed/30327310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0203
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