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Thiourea-Based Inhibitors of the B-Cell Lymphoma 6 (BCL6) BTB Domain via NMR-Based Fragment Screening and Computer-Aided Drug Design

Protein-protein interactions (PPI) between the transcriptional repressor B-cell lymphoma 6 (BCL6) BTB domain (BCL6(BTB)) and its co-repressors have emerged as a promising target for anti-cancer therapeutics. However, identification of potent, drug-like inhibitors of the BCL6(BTB) has remained challe...

詳細記述

保存先:
書誌詳細
出版年:J Med Chem
主要な著者: Cheng, Huimin, Linhares, Brian M., Yu, Wenbo, Cardenas, Mariano G., Ai, Yong, Jiang, Wenjuan, Winkler, Alyssa, Cohen, Sandra, Melnick, Ari, MacKerell, Alexander, Cierpicki, Tomasz, Xue, Fengtian
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6334293/
https://ncbi.nlm.nih.gov/pubmed/29969259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00040
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