Critical Residues within the BTB Domain of PLZF and Bcl-6 Modulate Interaction with Corepressors

The PLZF (promyelocytic leukemia zinc finger) transcriptional repressor, when fused to retinoic acid receptor alpha (RARα), causes a refractory form of acute promyelocytic leukemia. The highly conserved N-terminal BTB (bric a brac, tramtrack, broad complex)/POZ domain of PLZF plays a critical role i...

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Main Authors: Melnick, Ari, Carlile, Graeme, Ahmad, K. Farid, Kiang, Chih-Li, Corcoran, Connie, Bardwell, Vivian, Prive, Gilbert G., Licht, Jonathan D.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2002
Teme:
Transcriptional Regulation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC135611/
https://ncbi.nlm.nih.gov/pubmed/11865059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.6.1804-1818.2002
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