Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma

Diffuse large B cell lymphomas (DLBCLs) arise from proliferating B cells transiting different stages of the germinal center reaction. In activated B cell DLBCLs (ABC-DLBCLs), a class of DLBCLs that respond poorly to current therapies, chromosomal translocations and amplification lead to constitutive...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Cardenas, Mariano G., Yu, Wenbo, Beguelin, Wendy, Teater, Matthew R., Geng, Huimin, Goldstein, Rebecca L., Oswald, Erin, Hatzi, Katerina, Yang, Shao-Ning, Cohen, Joanna, Shaknovich, Rita, Vanommeslaeghe, Kenno, Cheng, Huimin, Liang, Dongdong, Cho, Hyo Je, Abbott, Joshua, Tam, Wayne, Du, Wei, Leonard, John P., Elemento, Olivier, Cerchietti, Leandro, Cierpicki, Tomasz, Xue, Fengtian, MacKerell, Alexander D., Melnick, Ari M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004937/
https://ncbi.nlm.nih.gov/pubmed/27482887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI85795
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