Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons

Local translation regulates the axonal proteome, playing an important role in neuronal wiring and axon maintenance. How axonal mRNAs are localized to specific subcellular sites for translation, however, is not understood. Here we report that RNA granules associate with endosomes along the axons of r...

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Veröffentlicht in:Cell
Hauptverfasser: Cioni, Jean-Michel, Lin, Julie Qiaojin, Holtermann, Anne V., Koppers, Max, Jakobs, Maximilian A.H., Azizi, Afnan, Turner-Bridger, Benita, Shigeoka, Toshiaki, Franze, Kristian, Harris, William A., Holt, Christine E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333918/
https://ncbi.nlm.nih.gov/pubmed/30612743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.11.030
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