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Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons

Local translation regulates the axonal proteome, playing an important role in neuronal wiring and axon maintenance. How axonal mRNAs are localized to specific subcellular sites for translation, however, is not understood. Here we report that RNA granules associate with endosomes along the axons of r...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Cell
Hauptverfasser: Cioni, Jean-Michel, Lin, Julie Qiaojin, Holtermann, Anne V., Koppers, Max, Jakobs, Maximilian A.H., Azizi, Afnan, Turner-Bridger, Benita, Shigeoka, Toshiaki, Franze, Kristian, Harris, William A., Holt, Christine E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333918/
https://ncbi.nlm.nih.gov/pubmed/30612743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.11.030
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